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KMID : 0363320080290030684
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.684 ~ p.702
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The Effects of Jibeakjihwanghwangami(JJHG) on Monocrotaline-induced Hypertensive Rats
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Kim Jong-won
An Joung-Jo
Cho Hyun-Kyoung
Yoo Ho-Rhyong
Seol In-Chan
Kim Yoon-Sik
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Abstract
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This experiment was performed to determine the effect of Jibeakjihwanghwangami(JJHG) on hypertension in monocrotaline-induced hypertensive rats. The results obtained were as follows : 1. JJHG showed a safety in cytotoxicity and toxicity of liver. 2. JJHG showed scavenging activity on DPPH free radicals and SOD-like activity. 3. JJHG showed an inhibitory effect on ACE. 4. JJHG significantly decreased blood pressure and pulse in monocrotaline-induced hypertensive rats. 5. JJHG significantly decreased the levels of plasma aldosterone in monocrotaline-induced hypertensive rats. 6. JJHG significantly decreased the levels of potassium in monocrotaline-induced hypertensive rats. 7. JJHG significantly decreased the levels of uric acid. BUN, and creatinine in monocrotaline-induced hypertensive rats. These results suggest that JJHG might be effective in treatment and prevention of hypertension.
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KEYWORD
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Jibeakjihwanghwangami(JJHG), hypertension, monocrotaline-induced hypertensive rats
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